gamble at something—risk money in a game of chance:
- The men got out a pack of Mexican cards and gambled at a game called “Coon-can.”
gamble in something—risk money by investing in a commodity:
- Matrons gambled in shares quite as wildly as did the unkempt disreputables from the oil fields.
gamble with something—
1. gamble using cards, dice, etc.:
- They had a pack of real cards and gambled with them at Grab.
2. risk smth.:
- After working as an apprentice for three years, there was no way he was going to gamble with his future.