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What’s up vs What’s up with

what’s up—

1. what is happening; what is going on:

  • You can keep up to date on what’s happening with legislation, new product research, or what’s up in your community.

2. (U.S. sl., also: whassup) is used as a greeting to someone you know well:

  • “Hi, Jim. What’s up?” “Oh nothing much…. How are you doing?”

what’s up with—what’s wrong with:

  • Four out of ten days I have had to weather tornado and flash flood warnings. What’s up with the weather?