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Difference between One could care less and One couldn’t care less

one could care less —(coll.) one is completely uninterested; one does not care at all:

  • He is a lethargic guy who drifts along from day to day. If a bill doesn’t get paid he could care less.

one couldn’t care less— = one could care less:

  • Though he was great with clients, he couldn’t care less about his support people or the follow-up work they did for him.