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Difference between Great at, Great in and Great with

great at somethinghighly proficient in an activity:

  • She is great at making up dishes and experiments all the time.

great in somethingexcelling in a subject:

  • She is great in math. She has a wonderful teacher that truly cares…

great with somethingvery skilful in the use of tools, etc.:

  • John is great with a bit of crayon.