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Difference between Clean someone out and Clean up on someone

clean someone out—(coll.) take everything from a person; deprive or cheat smb. of his money, etc.:

  • “She cleaned me out,” says Williams. “She used me to get to America.”

clean up on someone—(U.S. coll.) defeat an opponent (in a fight):

  • Chavez looked tired and Tszyu cleaned up on him, clocking him with a clean left hook and several right uppercuts.