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Difference between Have it large and Make it big

have it large—(UK sl., also: large it up) go out and enjoy oneself, typically with drink or drugs:

  • I was out last night till the very early hours of the morning having it large.

make it big—(coll.) become successful and famous:

  • If you want to make it big as a musician in the United States, the festival in Austin is a good place to start.